Levoximed in the Treatment of Acute Uncomplicated Pyelonephritis in Different Phases of Menstrual Cycle

Abstract

Despite the progress in the field of etiology, pathogenesis and development of new methods of diagnosis and treatment of urinary tract infections (UTI), they remain among of the most common bacterial diseases in women. Women are predisposed to UTI due to anatomical and physiological features (fluctuations in sex hormones levels during the menstrual cycle, pregnancy and childbirth), playing the role both in normal and pathological conditions (gynecological diseases and operations). The objective: to evaluate the clinical and bacteriological efficacy of levofloxacin in women with uncomplicated acute pyelonephritis (uAP) with the onset of the disease in different phases of the ovarian-menstrual cycle (OMC). Materials and methods. The study was conducted at urological departments of the Olexandrivska Clinical Hospital, Kyiv. 82 women of reproductive age were hospitalized for uAP. All of them underwent standard diagnostic procedures and were treated with levofloxacin. The Group-1 comprised 59 women with uAP, diagnosed in the period from the 20th to the 5th day of OMC. The Group-2 included 23 women with uAP, developed in the period from the 6th to the 19th day of OMC. Results. In women with uAP overall clinical efficacy of levofloxacin was 93% and bacteriological efficacy – 91.5%. In Group-2 in women with mild course both clinical and bacteriological effectiveness of treatment were 100%. Conclusion. The use of antibiotics with a broad spectrum of action, targeting most microorganisms and protozoa, reduces the reduces the costs associated with treatment and rehabilitation of women of childbearing potential. Levofloxacin demonstrates good efficacy, tolerability and safety in the complex treatment of acute uncomplicated pyelonephritis, which allows the use of this drug in clinical practice.