Abstract
MicroRNA-27a (miR-27a) is deemed to be an oncogene that plays an important role in development of various cancers, and single nucleotide polymorphism (SNP) of miR-27a can influence the maturation or aberrant expression of hsa-miR27a, resulting in increased risk of cancer and poor prognosis for non-small cell lung cancer (NSCLC). This study aimed to assess the effects of rs895819 within miR-27a on susceptibility and prognosis of NSCLC patients in 560 clinical confirmed cases and 568 healthy check-up individuals. Adjusted odds/hazard ratios (ORs/HRs) and 95% confidential intervals (CIs) were calculated to evaluate the association between rs895819 and the risk and prognosis of NSCLC. The results showed that allele A and genotype GG of rs895819 were significantly associated with an increased risk of NSCLC (38.9% vs 30.8%, adjusted OR=1.26, 95%CI=1.23-1.29 for allele G vs A; 18.1% vs 11.7%, adjusted OR=1.67, 95%CI=1.59-1.75 for genotype GG vs AA). Moreover, positive associations were also observed in dominant and recessive models (53.7% vs 49.9%, adjusted OR=1.17, 95%CI=1.13-1.20 for GG/AG vs AA; 18.1% vs 11.7%, adjusted=1.65, 95%CI=1.58-1.73). However, no significant association was found between rs895819 and the prognosis of NSCLC in genotype, dominant and recessive models. These results suggested that miR-27a might be involved in NSCLC carcinogenesis, but not in progression of NSCLC. The allele G, genotype GG and allele G carrier (GG/AG vs AA) of rs895819 might be genetic susceptible factors for NSCLC. Further multi-central, large sample size and well-designed prospective studies as well as functional studies are warranted to verify our findings.
Highlights
Due to high morbidity and mortality, malignant behaviors and lack of effective treatment, lung cancer is deemed to the leading cause of cancer-related deaths, worldwide
Accumulating evidences suggested that single nucleotide polymorphism (SNP) of related genes were significantly associated with the risk and prognosis of Non-small cell lung cancer (NSCLC)
No significant difference of NSCLC recurrence or death risk was observed in cases in comparison of male vs female, smoking vs no smoking, drinking vs no drinking, adnocarcinoma vs squamous cell carcinoma and others as well as well/moderate vs poor/ undifferentiated
Summary
Due to high morbidity and mortality, malignant behaviors and lack of effective treatment, lung cancer is deemed to the leading cause of cancer-related deaths, worldwide. According to cancer statistics in 2014, approximately 116,000 men and 108,210 women will be estimated with new NSCLC cases and 86,930 men and 72,330 women will die of the disease in USA (Siegel et al, 2014). In China, a total of 605,946 persons were diagnosed as new NSCLC patients, and 486,555 cases were died in 2010 (Chen et al, 2014). Non-small cell lung cancer (NSCLC) accounts for 80% of all lung cancer patients (Lee et al, 2006). It is well known that NSCLC is a complicated malignant with an intense crosstalk of genetic and environmental factors. Accumulating evidences suggested that single nucleotide polymorphism (SNP) of related genes were significantly associated with the risk and prognosis of NSCLC
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