Abstract
Aim: Myocardial infarction (MI) is the clinical complication predominately caused by coronary plaque buildup and rupture during the process of atherosclerosis. In the 9p21 locus two important risk haplotype blocks have been identified. The one that carries the risk for MI with the lead variant rs10757278 and another characterized to influence progression of the MI, with the lead variant rs518394. We have investigated association of the two genetic variants with the ST-elevated MI in the gender specific manner. We have also tested variants effect on p15 mRNA level as one of the possible mechanisms of the variants effect.
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