Abstract
A simple and selective LC method is described for the determination of Lafutidine in tablet dosage forms. Chromatographic separation was achieved on a c18 column using mobile phase consisting of a mixture of Phosphate buffer (KH2PO4) pH4.0: Acetonitrile (30:70v/v/v), with detection of 299nm. Linearity was observed in the range 60-140µg/ml for Lafutidine (r2 =0.999) for the amount of drugs estimated by the proposed methods was in good agreement with the label claim. From the above experimental results and parameters it was concluded that, this newly developed method for the simultaneous estimation of Lafutidine was found to be simple, precise, accurate and high resolution and shorter retention time makes this method more acceptable and cost effective and it can be effectively applied for routine analysis in research institutions, quality control department in meant in industries, approved testing laboratories, bio-pharmaceutical and bio-equivalence studies.
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