Abstract
目的 建立反相高效液相色谱法测定人血清中丙戊酸的药物浓度.方法 以symmetryshield RP18柱(5.0 μm,3.9 mm×150 mm)为色谱柱.流动相为甲醇∶水(80∶20),流速1.0 ml/min.Waters 2487双波长紫外检测器,检测波长248 nm.血清用正己烷提取,经α-溴苯乙酮衍生后浓集进样,以环己烷羧酸为内标物.结果 线性范围为5.0～250.0 μg/ml,r=0.9994;平均回收率为98.23%,高、中、低浓度样品的日间和日内测定相对标准偏差(RSD)均小于3%.绪论本法适用于丙戊酸的血药浓度测定。
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