Abstract
Nauclea latifolia Smith (Rubiaceae) are commonly prescribed in African traditional medicine as a remedy for a number of diseases including diabetes mellitus.1 Although a series of experimental animal studies have established its antidabetic activity little is known about the possible mechanism of its action.2, 3 This prompted us to investigate the in vitro inhibitory action of the methanolic extract of N. latifolia stem bark and fractions therefrom on human liver glycogen phosphorylase (HLGP).
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