Abstract
Thirty-eight tumors were induced in white-lipped marmosets(Saguinus nigricollis, S. fuscicollis) by the Schmidt-Ruppin strain of Rous sarcoma virus (SR-RSV). They were analyzed for viral genome, virus-expressed antigen(s), chromosomal aberrations, and the production of acid mucopolysaccharides (AMPS). Tumors established in cell cultures had morphologic characteristics typical for Roustumor cells of fowl and other mammalian species. The viral genome was demonstrated in 7 of 18 tumors by cocultivation with live, X-irradiated, or disrupted chicken cells. No group-specific antigen was detected by complement fixation tests (COFAL) in tumors examined, and only a few animals with a long latent period developed COFAL antibodies. Although no specific chromosomal aberrations accompanied marmoset SR-RSV-induced tumors, chromosomes were often broken and rearranged, which wasattributed to inadequate cell nutrition in fast-growing and poorly vascularized tumors. Large quantities of AMPS were demonstrated in some tumors, and all tumors had some AMPS on the periphery of tumors infiltrating surrounding muscles. Infectious viruses isolated from marmoset SR-RSV-induced tumors had envelope antigens similar to either subgroup A or D of avian sarcoma-leukosis viruses, as did the original SR-RSV used for marmoset inoculation.
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