Root extract and proanthocyanidins on oral bacteria viability - Nijole Savickiene

Abstract

Elevated proportions of some subgingival microbial species have been associated with destructive periodontal disease activity. Biologically active compounds of Pelargonium sidoides root extract (PSRE) or Proanthocyanidins (PACNs) from this extract modulate bacterial virulence and stimulate host immune responses. There is no local delivery system of sustained release formulations with PSRE or PACNs available, however, bioactive capacities of these substances suggest them as promising prolonged local periodontitis treatment candidates.