Abstract
Forty-one severely burned patients were divided into inhalation injury and non-inhalation injury groups. It was found that in the inhalation injury group, TXB 2 level and TXB 2/6-keto-PGF 1α ratio in both plasma and lung tissues were significantly elevated, circulatory platelet aggregate ratio markedly decreased, and blood viscosity greatly increased. Histopathologically, congestion, oedema, haemorrhage and thrombosis were observed in lung tissues taken from patients succumbing to respiratory failure. The changes in TXB 2 and TXB 2/6 keto-PGF 1α ratio accorded with the clinical course of the development of respiratory failure in burn patients with inhalation injury. It is proposed that the imbalance of TXA 2/PGI 2 plays an important role in the pathogenesis of respiratory failure in severely burnt patients complicated with inhalation injury.
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