Abstract
Roles of necroptosis in immune responses
Highlights
Programmed cell death, apoptosis, occurs in an orchestrated fashion when cells are subjected to death stimuli
Biological process of necroptosis was found in caspase8-compromised T cells and programmed cell death including apoptosis plays a key role in homeostasis of immune cells activated with specific antigens
Another protein MC159, viral FLICE-like inhibitory protein that encoded in human poxvirus Molluscum contagiosum virus (MCV), inhibits necroptosis, and caspase-8-induced apoptosis
Summary
Programmed cell death, apoptosis, occurs in an orchestrated fashion when cells are subjected to death stimuli. Necroptosis is executed by a cascade of cell signaling proteins in an orchestrated way in response to death stimuli such as TNFα and chemicals under a caspase-8 compromised condition. When it comes to immunology, cell death modes determine the physiological outcomes of immune responses in multicellular organism. Protecting TNF-α-induced systemic inflammatory responses [4], and suppressing metastasis of both melanoma cells and lung carcinoma cells in mice [5] Another RIP family member RIP3 was targeted by small molecules GSK’872, GSK’840 and GSK’843 [6]. GW806742X was found to bind to the KLD of MLKL, abrogating plasma membrane translocation of MLKL [9]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
