Abstract
Abnormal state of the maternal-fetal interface tolerance is one of the important reasons of unexplained recurrent miscarriage (URM), but its mechanism is not clear yet. Regulatory T (Treg) cells play an important role in the maintenance of maternal-fetal interface tolerance. The latest research has found that Toll like receptors may be the key to regulate proliferation, differentiation and function of Treg cells. The maternal-fetal interface of Toll like receptor 4 (TLR4) participates in the regulation of Treg cell inhibitory activity and the induction of trophoblast apoptosis, influences the balance of Treg/Th17, and may disturb the balance the immune tolerance and then cause URM. In this review, the mechanism of TLR4 regulating Treg cells in the pathogenesis of the URM decidua surface is reviewed. Key words: Unexplained recurrent miscarriage (URM); Toll like receptor 4 (TLR4); Maternal-fetal interface; Decidual; Regulatory T (Treg) cells
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
