Role of the renin-angiotensin system in renal hypertension. An experimental approach.

Abstract

In 1898 Tigerstedt and Bergman first detected the existence of renal renin and discussed its possible role in the development of cardiac hypertrophy associated with various kidney diseases. Hartwich (1930) and Goldblatt et al. (1934) were able to produce persistent arterial hypertension in dogs by narrowing the renal arteries. Subsequently, a large number of findings accumulated in the field of renal hypertension. Most of the material has been covered in reviews edited by Braun-Menendez (1946), Page and McCubbin (1968), and Page and Bumpus (1974). There is general agreement that arterial hypertension, including renal hypertension, is a multifactorial disorder of regulation as anticipated by Page in 1949 when he proposed his concept known as the mosaic theory.