Abstract
Abstract Chronic experimental renal hypertension in dogs has been successfully treated with crude and semipurified hog renins and chronic experimental renal hypertension in dogs has been prevented by prophylaxis with crude and semipurified hog renins. These therapeutic and prophylactic effects are well-correlated with the antirenin titer. This evidence for antirenin (or an antibody to a protein closely related to renin) as the mechanism of the antihypertensive effects of hog renins constitutes support for the affirmative of the long-standing controversy regarding the primary role of renin (or some closely related protein) in the pathogenesis of experimental renal hypertension. Hog renal medulla contains a factor which interferes with the antihypertensive effects of hog renin in experimental renal hypertension in the dog by a mechanism presently unknown. Renotoxic and renal protective factors have been found to occur in fractions of renal extracts. Toxicity consists in increased and protection in decreased incidence of uremia after constriction of the renal arteries. After further preliminary experiments in animals, the possible pathogenetic role of the kidney in essential hypertension will be studied by passive immunization of patients with purified antirenin to human renin.
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