Abstract
The effects of hypothalamic lesions on cinchophen-induced gastric ulcers were studied in 38 male mongrel dogs. Chronic gastric ulcers were produced in 100% of the cinchophen-administered dogs without hypothalamic lesion. When cinchophen was administered to animals with anterior, posterior and lateral hypothalamic lesions, this incidence of gastric ulcers was not prevented. In dogs with lesions of the middle portion of the hypothalamus, the incidence of chronic ulcers was decreased two-thirds; in dogs with lesions of the ventromedial nuclei of the hypothalamus, goldthioglucose did not protect against the development of cinchophen ulcers. Chronic gastric ulcers were not produced in all of the dogs with lesions of the median eminence. These data suggest that daily administration of cinchophen produced gastric ulcers in the pyloric region through the mechanism of the median eminence.
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