Abstract
SummaryIn the intact rat low doses of Orinase produced a significant depression of blood sugar and deposition of liver glycogen while higher doses were ineffective. The adrenalectomized rat was found to be approximately 10 times as sensitive and the adrenal demedullated rat 3-6 times more sensitive to Orinase than the intact rat. Hydrocortisone partially and epinephrine completely counteracted the hypoglycemic effects of Orinase. Failure of high doses of this sulfonylurea to produce hypoglycemia and liver glycogen deposition in the intact rats may be due to a stimulation of epinephrine secretion by the adrenal medulla. It is also suggested that glucocorticoid secretion is also stimulated by high doses of Orinase in the intact and adrenal demedullated animals.
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