Role of Th17 Cells in Tumor Immunity: A Double Edged Sword

Abstract

Objectives: Th17 cells are another CD4+T cell group after the discovery of the Th1, Th2 cell subsets, which can secrete IL-17A and Il-6. Th17 cells play a role in autoimmunity，inflammation and maintaining immune stability. Seldom studies are about the role of Th17 in tumor, research progress of Th17 cells in tumor immunity was described in this paper. Methods: we search the latest research in the world related to progress of Th17 cells in internet, and describe the progress of Th17 cells in tumor immunity. Results: The role of Th17 cells in tumor immune response is diverse. Some researchers have found that Th17 plays an anti-tumor immune response, while in other studies. Th17 cells play the opposite role. The role of Th17 cells in the local tumor seems to have two sides. Conclusions: The role of Th17 in tumor immunity is not very clear until now. Conflict idea exists in research reports. Are Th17 cells exerting regulatory roles in tumor site like Treg cells? It remains to be explored further. With more scientists in the field of Th17 research, the role of Th17 cells in tumor immunity will be further revealed.