Abstract
The reversed pH gradient across the cell membrane on account of intracellular alkalinization and extracellular acidosis is an importart characteristic of tumor microenvironment. Sodium hydrogen exchanger isoform 1 (NHE1) is ubiquitously expressed at the plasma membrane of many types of cells, which plays a cri-tical role in intracellular pH and cell volume homeostasis. NHE1 plays an important role in the regulation of tumor microenvironment and involves in tumor migration and invasion, which may be a potential new target in anti-cancer therapy. Key words: Acid-base equilibrium; Neoplasm invasiveness; Cell movement; Tumor microenvironment; Sodium hydrogen exchanger isoform 1
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