Role of small dense LDL-cholesterol in detecting the risk of cardiovascular disease among smokers

Abstract

Coronary heart disease is the leading cause of the death and disability in the developed nations and is increasing rapidly in the developing countries. Study aimed to estimate and compare the small dense LDL-cholesterol (sdLDL-C) in healthy smokers & non-smokers. This is analytical observational study, conducted at father Muller medical college Mangalore after approval from the institutional Research & Ethics committee. The subjects were selected from the patients coming for the routine health checkups to the hospital. The participants willing to be part of study between the age group of 25-65yrs of age, with history of cigarette smoking were grouped as group II and healthy non-smokers as group I. A 3ml of fasting blood sample was drawn under all precautionary measures and subjected to analysis at central laboratory biochemistry section after separating the serum. Total of 760 normal healthy individuals were included in the current study with 480 healthy cigarette smokers and 280 healthy non-smokers. Lipid profile showed a significant difference between the smokers and non-smokers with elevated LDL cholesterol and the sdLDL cholesterol and reduction in level of HDL cholesterol among the smokers compared to non-smokers. There is a significant higher level of small dense LDL cholesterol among the smokers compared to non-smokers, which can help to predict the risk for future cardiovascular bad events among the smokers.