Abstract
β-thalassemia is characterized by anemia and depending on the severity of the anemia. Hepcidin is a 25-amino-acid peptide generated by the liver, based on hypoxia, anemia, and iron storage. controls blood iron concentration and tissue distribution and regulates the body's iron hemostasis. To evaluate the usefulness of Serum Hepcidin level as a biochemical marker of iron status in children with β thalassemia major, β thalassemia Intermedia and its relation with serum ferritin level. A cross-section study which will involve 90 included 50 Thalassemia Major (TM) and 40 Thalassemia Intermedia (TI). Patients will be collected from the thalassemia center in Kut Hospital for Gynecology and Pediatrics, were randomly selected for this study. All patients child in both gender from (5-17 years). Enzyme-linked immunosorbent assay [ELISA] used for determination of Hepcidin, Abbott Architect C4000 And cobas c 111 analyzer used for the determination of Ferritin, Iron and Hemoglobin was measured by Sysmex XP-300. The study included both gender 62.2% were male and 37.8% were females, regarding male gender 57.1% had βTM and 42.9% had βTI while female gender 52.9% had B-thalassemia major and 47.1% had β-thalassemia Intermedia.
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