Abstract
Studies in recent years have demonstrated that stromal cell-derived factor-1 （SDF-1）/CXCR4 axis plays an important role in the process of angiogenesis. The expression of SDF-1 in ischemic tissue increases during cerebral ischemia. It binds to CXCR4 receptor on the surface of endothelial progenitor cells （EPCs）, and thus promotes bone marrow-derived EPC mobilization, proliferation, and migration to the ischemic areas and homing. EPCs differentiate into mature erttothelial cells in the ischemic region, promote the formation of new blood vessels, and thus improve the blood supply to ischemic tissue. This article reviews the effect of SDF-1/CXCR4 axis in the treatment of cerebral ischemia with EPCs Key words: chemoldne CXCL12; receptors, CXCR4; endothelial cells; stem cells; cerebral ischemia
Published Version
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