Abstract
Clerodendrum serratum: A clinical approachMukesh Kr. Singh, Gaurav Khare, Shiv Kr. Iyer, Gotmi Sharwan, D. K. Tripathi
Highlights
The use of traditional Chinese medicine (TCM) for the prevention and treatment of cancer has generated much interest
Scutellarin is a flavone glycoside isolated from Erigeron breviscapus, a perennial herb of the daisy family Asteraceae
Scutellarin reduced reactive oxygen species production and induced apoptosis of liver cancer cells by inhibiting the signal transducer and activator of transcription (STAT) 3 pathway, and transcriptional targets of Bcl-XL and Mcl-1 (Xu and Zhang, 2013). These findings were reaffirmed by a recent study that scutellarin suppressed migration and invasion of liver cancer cells by inhibiting the activities of STAT3, Girdin, and AKT (Ke et al, 2017)
Summary
The use of traditional Chinese medicine (TCM) for the prevention and treatment of cancer has generated much interest. Scutellarin induces apoptosis and cell cycle arrest and inhibits proliferation and progression of a wide spectrum of human cancer cells. Of particular interest are the multiple molecular targets and pathways of the compound toward a wide spectrum of human cancer cells, structure-activity relationships of cytotoxicity, and future research. Scutellarin induces apoptosis and cell cycle arrest and inhibits proliferation and progression of cancer cells via multiple molecular targets and pathways (Wang and Ma, 2018).
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