Abstract
Norepinephrine and epinephrine contents in oral, esophageal, and gastric mucosa are studied in rats by high-performance liquid chromatography 24 h, 3 days, and 7 days after removal of the main salivary glands. A 24-h deficiency of saliva leads to a sharp decrease in the norepinephrine contents in oral and esophageal mucosa. Three days after the surgery, norepinephrine content is normalized in the mucosa of the upper gastrointestinal tract. The most pronounced changes in the contents of both catecholamines in the mucosa of the upper gastrointestinal tract were observed on day 7. Severe insufficiency of salivation caused pronounced phasic changes in the catecholamine contents, indicating that the mucosa of the esophagus and lesser and greater curvatures of the stomach receive catecholamines from saliva. Insufficient supply of saliva leads to the development of inflammatory and dystrophic processes in esophageal and gastric mucosa.
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