Abstract
The article is aimed to summarize the scattered data on the role of peroxisome proliferator-activated receptors (PPAR) and the possibility of using PPAR’s agonists for treatment of alcohol dependence and alcoholic liver disease. Earlier it was shown that some PPAR agonists can reduce ethanol consumption and preference in rodents. Several hypotheses considering the antialcoholic activity of PPAR agonists and the roles of PPAR in the development of alcohol dependence were discussed. In light of these data, the therapeutic potential of PPARs agonists as an agent for the treatment of alcoholism, has been reviewed.
Highlights
The article is aimed to summarize the scattered data on the role of peroxisome proliferator-activated receptors (PPAR) and the possibility of using PPAR’s agonists for treatment of alcohol dependence and alcoholic liver disease
Earlier it was shown that some PPAR agonists can reduce ethanol consumption and preference in rodents
Several hypotheses considering the antialcoholic activity of PPAR agonists and the roles of PPAR in the development of alcohol dependence were discussed
Summary
The article is aimed to summarize the scattered data on the role of peroxisome proliferator-activated receptors (PPAR) and the possibility of using PPAR’s agonists for treatment of alcohol dependence and alcoholic liver disease. Зависимые от пола животных, были зарегистрированы и в других исследованиях агонистов PPARs, например в исследовании действия различных препаратов на развитие болевой гиперчувствительности у мышей разных линий (Crl:ICR, Crl:CD1-Foxn1nu, C57BL/6J, Rag1−/−), где показано, что фенофибрат снижает аллодинию и гипералгезию только у самцов, но не у самок мышей, тогда как пиоглитазон действует только на самок, но не на самцов [30].
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