Abstract
Pharmacological and Toxicological Advances in PPAR-Related Medicines
Highlights
The paper “Peroxisome proliferator-activated receptors (PPARs) medicines and human disease: The ATP-dependent binding cassette (ABC) of it all” by A
Nicol is a review article that summarizes the advances of knowledge concerning effects of PPAR medicines on ATP-dependent binding cassette (ABC) transporters based on in vitro, in vivo, and human clinical trial studies
This review suggests the potential of PPAR-related medicines for controlling ABC transporter activity at the transcriptional level, and discusses their potential implications in human diseases with respect to cancer and atherosclerosis
Summary
The paper “PPAR medicines and human disease: The ABCs of it all” by A. Many types of PPAR-related medicines developed and utilized clinically all over the world exert multiple effects, including regulation of hypolipidemic, antidiabetic, antiinflammatory, antifibrotic, and antiproliferative pathways, with emerging potential benefits in other diseases. Nicol is a review of the vast in vitro, in vivo, and human clinical trial studies, using chemotherapeutic combinations that include PPARγ activating drugs.
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