Role of opportunity of nasal continuous positive airway pressure on the prognosis of neonatal respiratory distress syndrome

Abstract

Objective To investigate the Role of opportunity of nasal continuous positive airway pressure on the prognosis of neonatal respiratory distress syndrome. Methods A total of 120 neonates with respiratory distress syndrome in the Fifth Affiliated Hospital of Zhengzhou University from October 2016 to October 2018 were included as study subjects. According to the timings of nasal continuous positive airway pressure, the neonates were divided into early stage group (within 8 h after birth) and advanced stage group (within 8 h to 12 h after birth), with 60 cases in each group. The clinical efficacy was compared between the two groups after 24 h of treatment. The blood gas analysis indexes, such as partial pressure of carbon dioxide (PaCO2), partial pressure of blood oxygen (PaCO2), pH, and continuous positive airway pressure parameters, such as fraction of inspired oxygen (FiO2), positive end expiratory pressure (PEEP) before and 24 h after treatment of the two groups were recorded. The lung function indexes, such as respiration rate (RR), tidal peak expiratory flow (PEF), time to peak expiratory flow (TPEF), peak volume ratio (VPEF/VE) 24 h after treatment were recorded in the two groups. Results After 24 h of treatment, the total effective rate of treatment in early stage group (96.67%, 58/60) was significantly higher than that in advanced stage group (85.00%, 51/60), P 0.05). There were no significant differences in the PEF and VPEF/VE between the two groups (P>0.05), and the RR in early stage group was larger than that in advanced stage group, and the TREF was smaller than that in advanced stage group (P all <0.05). Conclusions Early application of nasal continuous positive airway pressure can improve the treatment effects of neonatal respiratory distress syndrome and promote pulmonary ventilation function of children. Key words: Nasal continuous positive airway pressure; Neonates; Respiratory distress syndrome; Pulmonary function