Effects of curosurf on pulmonary ventilation and oxygenation capacity of newborns with neonatal respiratory distress syndrome

Abstract

Objective To investigate the effect of curosurf on pulmonary ventilation and oxygenation capacity of newborns with neonatal respiratory distress syndrome (NRDS). Methods The clinical data of 102 children with NRDS were analyzed retrospectively. Children were randomly divided into group A and group B, with 51 cases in each group. The group A was treated by nasal continuous positive airway pressure (NCPAP), group B was given curosurf treatment on the basis of treatment of group A. The therapeutic effect, incidence of complications, fatality rate, pulmonary ventilation and oxygenation were compared between the two groups. Results After treatment, the partial pressure of carbon dioxide (PaCO2) in group B was lower than that of group A, and the level of arterial oxygen partial pressure (PaO2) and arterial oxygen saturation (SaO2) in group B were higher than those in group A; the oxygen concentration (FiO2), positive end expiratory pressure (PEEP) and peak inspiratory pressure (PIP) in group B were all lower than those in group A (all P 0.05. Conclusions Curosurf treatment has significant effects on NRDS patients, it can improve pulmonary ventilation function and oxygenation capacity, and has great value of application. Key words: Neonatal respiratory distress syndrome; Curosurf; Pulmonary ventilation; Oxygenation property