Abstract
Bone homeostasis is mainly regulated by osteoblasts, osteocytes and osteoclasts. Osteoblasts promote bone formation and osteoclasts stimulate bone resorption. Bone loss with aging is due to decreased osteoblastic bone formation and increased osteoclastic bone resorption. Bone loss with various pathophysiologic states leads to osteoporosis. Nutrition and functional food factors may play a role in the prevention of bone loss. Menaquinone-7 (MK-7), a kind of vitamin K 2 , has been shown to reveal stimulatory effects on osteoblastic bone formation and suppressive effects on osteoclastic bone resorption in vitro. MK-7 stimulates protein synthesis (including osteocalcin and other protein molecules) in osteoblastic cells. MK-7 regulates the gene expression of various proteins, which are related to cellular functions in osteblastic and osteoclastic cells. MK-7 suppresses activation of NF-κB signaling pathways in osteoblasts and osteoclasts. Moreover, dietary intake of MK-7 has been shown to reveal potential preventive effects on bone loss in osteoporosis animal models and postmenopausal women. This review will discuss the role of dietary MK-7 in the prevention of osteoporosis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
