Abstract
Abstract: Multiciliated cells of airway epithelium are terminally differentiated cells which are involved in the mucociliary clearance and trapping pathogens and particulate matter. Previous works have shown the transdifferentiation of secretory club cells to ciliated cells upon inhibition of Notch signaling. But, none of the existing literature reports presence or role of Notch signaling in multiciliated cells of airway epithelium. Immunostaining for Notch Intracellular Domain (NICD) revealed the presence of Notch signaling in multiciliated cells of the airway. The basic aim of this paper is to understand whether there is a role of Notch signaling in ciliated cells, by doing a cell autonomous ablation of Notch in this particular cell type using FOXJ1 CreErtm/+ RBPJkflox/flox animals. We didn’t observe any obvious change in cellular architecture of lung or any difference in club or ciliated cell numbers.
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