Abstract
Abstract: Fibrodysplasia Ossificans Progressiva (FOP), commonly known as Stoneman Syndrome, is an ultra-rare genetic disorder characterized by the progressive ossification of soft tissues, leading to the formation of a secondary skeleton. This paper provides a comprehensive analysis of FOP, examining its epidemiology, pathophysiology, clinical manifestations, diagnostic criteria, and current treatment approaches. Through a review of the latest research and case studies, this paper also explores the psychological and social impact of the disease, the challenges faced by patients, and the future directions for potential therapies. With fewer than 1,000 confirmed cases worldwide, FOP remains one of the most enigmatic and debilitating conditions in modern medicine.
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