Abstract
Implantation of crystalline physostigmine in the substantia nigra in rats resulted in compulsive gnawing behavior, which has also been found to result from dopa or apomorphine implantation in the neo-striatum. Atropine pretreatment prevented the effect of physostigmine implants. It is concluded that dopaminergic nigro-neostriatal fibers play a role in gnawing behavior, and that these fibers are activated by cholinergic transmission.
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