Abstract
Mitochondria are essential intracellular organelle to produce ATP through aerobic respiration. Therefore, mitochondrial dysfunction by the accumulation of various intracellular stresses has a significant impact on cellular functions. Moreover, previous studies reported that mitochondrial DNA (mtDNA) leaking into cytosol influences intracellular signalings such as cGAS-STING or NF-κB pathways under mitochondrial dysfunction states. We recently defined that the cytosolic mtDNA enhanced the type I Interferon (IFN) production in microglia, a resident immune cell in central nerve systems (CNS), in the context of mitochondrial dysfunction. It is known that mitochondrial function was impaired in the brains of elderly and patients with neurodegenerative diseases. In addition, IFN is involved in the pathophysiology of depression and Alzheimer's disease. In this workshop, we will introduce these recent findings and discuss the potential of drugs that modulate this pathway as prophylactic and therapeutic agents for these CNS diseases.
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