Abstract

MicroRNAs (miRNAs) are short non-coding RNAs that play an important role in the regulation of gene expression. In addition to being encoded by the host cells, miRNAs are also encoded by certain DNA and RNA viruses, blurring the lines between host and viral genetic regulation. This duality allows miRNAs to assume both antiviral and proviral roles in the viral life cycle. Furthermore, miRNAs exert profound influence over immune responses, viral latency, host susceptibility to infections, cellular differentiations and pathways governing programmed cell death. In this comprehensive discussion, we delve into the current state of knowledge regarding miRNAs, including the diverse types of miRNAs, such as canonical and viral miRNAs, and explore their multifaceted roles in virus replication, pathogenesis, and immune modulation. This exploration enhances our understanding of the intricate interplay between viruses and their host organisms and encompasses various other RNA molecules that contribute to this dynamic landscape.

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