Abstract
MicroRNA-221/222 (miRNA-221/222, miR-221/222) is a noncoding microRNA which is widely distributed in eukaryotic organisms and deeply involved in the posttranscriptional regulation of gene expressions. According to recent studies, abnormal expressions of miR-221/222 are closely related to the occurrence and development of various kinds of malignant tumors. The role of miR-221/222 in tumor development and their potential molecular mechanism in various cancers, including liver cancer, colorectal cancer, cervical cancer, ovarian cancer, and endometrial carcinoma, are summarized and reviewed in this paper. Moreover, the potential translational biomarker role of abnormal miR-221/222 level in tumor or blood circulation for tumor diagnosis is also discussed.
Highlights
MicroRNAs are short, endogenous, noncoding RNAs with a length of 18–25 nucleotides
MicroRNA-221/222 is a noncoding microRNA which is widely distributed in eukaryotic organisms and deeply involved in the posttranscriptional regulation of gene expressions [1,2,3,4]
Sun et al [67] observed that the expression of miR-222 in cervical cancer tissue was 2.48 times higher than that in normal tissues adjacent to cancer according to the samples of 18 patients. e upregulation of miR-222 was correlated with the deterioration of cervical cancer, and the analysis showed that p27/Kip1 and PTEN were negatively correlated with miR-222, which affected the proliferation and migration of Hela cells and SiHa cells, suggesting that miR-222 might be a new target for cervical cancer therapy
Summary
Received 10 June 2019; Revised 22 October 2019; Accepted 1 November 2019; Published 24 December 2019. MicroRNA-221/222 (miRNA-221/222, miR-221/222) is a noncoding microRNA which is widely distributed in eukaryotic organisms and deeply involved in the posttranscriptional regulation of gene expressions. Abnormal expressions of miR-221/222 are closely related to the occurrence and development of various kinds of malignant tumors. E role of miR-221/222 in tumor development and their potential molecular mechanism in various cancers, including liver cancer, colorectal cancer, cervical cancer, ovarian cancer, and endometrial carcinoma, are summarized and reviewed in this paper. The potential translational biomarker role of abnormal miR-221/222 level in tumor or blood circulation for tumor diagnosis is discussed
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