ROLE OF MESENCHYMAL STEM CELLS IN CARDIOVASCULAR DISEASE

Abstract

In recent years, globally there is an incredible boost in stem cell research has kindled the expectations of both patients and physicians. Mesenchymal stem cells (MSCs) seem to represent a future powerful tool in regenerative medicine, owing to their availability, ease of manipulation, and therapeutic potential, therefore they are particularly important in medical research. Mesenchymal stem cells (MSCs) are capable self-renewing, multipotent progenitor cells with multilineage potential to differentiate into cell types, such as adipocytes, cardiomyocytes, endothelial cells and vascular smooth muscle cells, although the relative contribution of trilineage differentiation and paracrine effectors on cardiac repair. MSCs shows to have the beneficial effects of MSC-based therapies offers most attractive options to treatment of wide range of diseases from cartilage defects to cardiac disorders. Cardiovascular diseases (CVDs) are an important cause of death and disease worldwide. Because injured cardiac tissue cannot be repaired itself, it is urgent to develop other alternate therapies. Stem cells can be differentiated into cardiomyocytes, endothelial cells, and vascular smooth muscle cells for the treatment of CVDs. In addition to cardiac stem cells, mesenchymal stem cells represent another multipotent cell population in the heart; these cells are located in regions near pericytes and exhibit regenerative, angiogenic, antiapoptotic, and immunosuppressive properties.