Role of mast cells in pulmonary damage after Androctonus astralis hector scorpion envenoming

Abstract

Event Abstract Back to Event Role of mast cells in pulmonary damage after Androctonus astralis hector scorpion envenoming Imene Chaïr-Yousfi1, Fatima Laraba-Djebari1* and Djelila Hammoudi-Triki1 1 USTHB, Cellular and Molecular Biology, Algeria Pulmonary edema is responsible for most of the severe cases of poisoning and death, in the scorpion envenomation pathogenesis. Mast cells can release a range of mediators known to be involved in the development of lung edema following venom injection. The present study investigated the role of the mast cells in inflammatory response after Androctonus australis hector (Aah) scorpion envenoming. To this end, mast cells were depleted using Compound 48/80. Pulmonary edema was also assessed by measuring the amount of Evans blue dye extravasation in the bronchoalveolar lavage, in the peritoneal liquid and in the lung. Our results demonstrate an important role for mast cells in the development of lung injury, and an increase of vascular permeability in mice following the subcutaneous administration of Aah venom. Keywords: Lung Injury, Androctonus australis hector, scorpion venom, Mast Cells, Compound 48/80, Evans blue dye, Plasma extravasation Conference: The First International Congress of Immunology and Molecular Immunopathology (CIMIP2014), Tlemcen, Algeria, 17 Oct - 20 Oct, 2014. Presentation Type: Poster Presentation Topic: Immunity – Nutrition – Cancer Citation: Chaïr-Yousfi I, Laraba-Djebari F and Hammoudi-Triki D (2014). Role of mast cells in pulmonary damage after Androctonus astralis hector scorpion envenoming. Front. Immunol. Conference Abstract: The First International Congress of Immunology and Molecular Immunopathology (CIMIP2014). doi: 10.3389/conf.fimmu.2014.04.00022 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 28 Sep 2014; Published Online: 01 Dec 2014. * Correspondence: Prof. Fatima Laraba-Djebari, USTHB, Cellular and Molecular Biology, Beb Ezzouar, Algeria, flaraba@hotmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Imene Chaïr-Yousfi Fatima Laraba-Djebari Djelila Hammoudi-Triki Google Imene Chaïr-Yousfi Fatima Laraba-Djebari Djelila Hammoudi-Triki Google Scholar Imene Chaïr-Yousfi Fatima Laraba-Djebari Djelila Hammoudi-Triki PubMed Imene Chaïr-Yousfi Fatima Laraba-Djebari Djelila Hammoudi-Triki Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.