Abstract
Abstract Background: Rhinosinusitis, a group of disorders characterized by inammation of the nose and paranasal sinuses can be classied as acute, sub-acute or chronic and recurrent based on the duration of inammation. Biolm with formation of a physical barrier prevent antibiotics from penetrating it. Macrolides achieve high intracellular concentration and have a spectrum of activity against Gram positive cocci. This study aims to describe effect of macrolide antibiotics (clarithromycin) on eradication of suspected biolms in chronic rhinosinusitis.
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