Abstract
Introduction: Lung cancer is the most common primary tumor associated with malignant pleuraleffusion (MPE). In this study, we aim to use cell remnants for cell block preparation after performingliquid-based cytology (LBC) of effusion fluid. Immunohistochemistry was helpful to evaluate thosecases having diagnostic dilemmas in LBC and cell block. Method: It was a cross-sectional,prospective, single institution-based study, conducted in the department of Pathology incollaboration with the Department of Respiratory Medicine IPGMER & SSKM Hospital, from January2018 to June 2019 in the institution. Result: Most of the study population were in between the agegroup of 51 to 60 years with male predominance and with fever and cough being the predominantsymptoms. Liquid-based cytology was positive for malignancy in 58% of cases and suspicious ofmalignancy in 22% of cases of malignant pleural effusion and it had 95.35% sensitivity, 58.82%specificity in diagnosing malignant pleural effusion.LBC was done followed by cell block preparationsare studied further by Immunohistochemistry. Discussion: Morphological features were betteridentified by the cell block method when compared to LBC. Multiple sections can be obtained forspecial stain or IHC study which bridges the gap between cytology and histology.
Highlights
Lung cancer is the most common primary tumor associated with malignant pleural effusion (MPE)
Morphological features were better identified by the cell block method when compared to liquid-based cytology (LBC)
Adenocarcinoma represents the most frequent histologic type of lung cancer to result in a malignant pleural effusion presumably because adenocarcinomas comprise a greater proportion of peripheral cancers than the other histologic types [1]. followed by squamous cell carcinoma, small cell carcinoma, and large cell undifferentiated carcinomas [2]
Summary
Lung cancer is the most common primary tumor associated with malignant pleural effusion (MPE). We aim to use cell remnants for cell block preparation after performing liquid-based cytology (LBC) of effusion fluid. Liquid-based cytology was positive for malignancy in 58% of cases and suspicious of malignancy in 22% of cases of malignant pleural effusion and it had 95.35% sensitivity, 58.82% specificity in diagnosing malignant pleural effusion.LBC was done followed by cell block preparations are studied further by Immunohistochemistry. Malignant pleural effusion (MPE), a common complication of cancer cell metastasis to the pleura is characterized by the proliferation of cancer cells in the pleura leading to abnormal fluid collection. Lung cancer is the most common primary tumour associated with malignant pleural effusion (MPE). A pleural effusion may develop when there is excess pleural fluid formation or when there is decreased pleural fluid removal by the lymphatics
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