Role of iron in pathogenesis of guinea pigs infected with Yersinia enterocolitica 0:3.

Abstract

Examined have been the pathogenesis of guinea pigs preliminarily overload with iron, and infected with Yersinia enterocolitica 0:3 in a logarithmic and stationary phase of development, cultivated at 25 degrees C and 37 degrees C. Dextrofer-100 (Fedex-100) medicine have been used as an iron source. The results show that in spite of the phase of development and cultivation temperature, the iron excess does not increase the bacterial virulence of the strain used so far. The morphological changes in the mesenterial lymphatic nodes, small intestines, spleen and liver of guinea pigs treated with iron, and then, infected with Y. enterocolitica, are more slightly expressed as compared with animals infected with Y. enterocolitica only. The investigations suggested so far, have attested that Yersinia enterocolitica 0:3 does not contain a gene responsible for the synthesis of the protein participating in iron uptake.