Abstract
Objective. Chronic asthma is characterized by an ongoing recruitment of inflammatory cells and airway hyperresponsiveness leading to structural airway remodeling. Although α4b1 and β2 integrins regulate leukocyte migration in inflammatory diseases and play decisive roles in acute asthma, their role has not been explored under the chronic asthma setting. To extend our earlier studies with α4Δ/Δ and β2L/L mice, which showed that both α4 and β2 integrins have nonredundant regulatory roles in acute ovalbumin (OVA)-induced asthma, we explored to what extent these molecular pathways control development of structural airway remodeling in chronic asthma.
Published Version
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