Abstract
Recent studies have demonstrated that innate immunity-related cytokines play an important role in human fungal infections, including interleukin-1β (IL-1β) , IL-4, IL-6, IL-10, IL-12, IL-17, IL-23, tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) . These cytokines dramatically affect sequelae of fungal infections through mediating innate immune response and shaping adaptive immune response via determining the direction of T helper type 0 (Th0) cell differentiation. According to the reaction sequence of pathogenic fungi-innate immune cells-cytokines-target cells-biological effects , the authors summarize cellular sources and basic functions of, as well as interactions between major cytokines associated with innate immunity in human fungal infections, list and analyze fungal infections due to dysfunctions of these cytokines caused by various reasons, which may help to find more targets for the treatment of these fungal infections. Key words: Dermatomycoses; Cytokines; Dendritic cells; Interleukins; Tumor necrosis factors; Interferon-gamma
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: International Journal of Dermatology and Venereology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.