Abstract
Recent studies have demonstrated that innate immunity-related cytokines play an important role in human fungal infections, including interleukin-1β (IL-1β) , IL-4, IL-6, IL-10, IL-12, IL-17, IL-23, tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) . These cytokines dramatically affect sequelae of fungal infections through mediating innate immune response and shaping adaptive immune response via determining the direction of T helper type 0 (Th0) cell differentiation. According to the reaction sequence of pathogenic fungi-innate immune cells-cytokines-target cells-biological effects , the authors summarize cellular sources and basic functions of, as well as interactions between major cytokines associated with innate immunity in human fungal infections, list and analyze fungal infections due to dysfunctions of these cytokines caused by various reasons, which may help to find more targets for the treatment of these fungal infections. Key words: Dermatomycoses; Cytokines; Dendritic cells; Interleukins; Tumor necrosis factors; Interferon-gamma
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