Abstract
Inflammation is part of the body′s response to invading pathogens and a crucial process in the maintenance of homeostasis. A variety of regulatory mechanisms are involved in inflammation process to limit the damage caused by excessive immune response to the host. Previous studies have shown that insulin resistance, type 2 diabetes, liver fibrosis and cardiovascular disease are caused by persistent chronic inflammation in metabolic tissue (brain, fat, liver, pancreas, etc), especially in adipose tissue. However, the underlying mechanisms of these conditions have not been fully understood. The role of innate and adaptive immune cells in these diseases attracts increasing attention. In this review, we will focus on the role of various immune cells in adipose tissue in the initiation and development of inflammation and discuss the efficacy of potential anti-inflammatory therapies based on their mechanisms. Key words: Adipose tissue; Chronic inflammation; Immune cell; Metabolism
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