Abstract
BackgroundPersistent allergic airway diseases cause a great burden worldwide. Their pathogenesis is not clear enough. There is evidence that one of the recently described cytokine interleukin (IL) 22 may be involved in the pathogenesis of these diseases. Scientists argue if this cytokine acts as proinflammatory or anti-inflammatory agent. The aim of this study was to investigate IL-22 level in patients with persistent allergic airway diseases caused by house dust mite (HDM) in comparison with healthy individuals and to evaluate its relationship with IL-13 and IL-10 level, symptoms score and quality of life.MethodsPatients with persistent allergic rhinitis caused by HDM and having symptoms for at least 2 years with or without allergic asthma were involved into the study. Measurements of IL-22, IL-13 and IL-10 and in serum and nasal lavage was performed by ELISA. Questionnaires assessing symptoms severity and quality of life were used.ResultsA tendency was observed that IL-22 in serum and nasal lavage was higher in patients with allergic airway diseases compared to control group (14.86 pg/ml vs. 7.04 pg/ml and 2.67 pg/ml vs. 1.28 pg/ml, respectively). Positive statistically significant correlation was estimated between serum IL-22 and serum IL-10 (rs = 0.57, p < 0.01) and IL-13 (rs = 0.44, p < 0.05) level. Moreover, positive significant correlation was found between IL-22 in nasal lavage and IL-10 in nasal lavage (rs = 0.37, p < 0.05). There was a negative statistically significant correlation between serum IL-22 and Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) (rs = − 0.42, p < 0.05).ConclusionOur study showed a possible anti-inflammatory effect of IL-22 in patients with persistent allergic airway diseases caused by HDM.
Highlights
Persistent allergic airway diseases cause a great burden worldwide
Duration of rhinitis symptoms was slightly longer in patients with allergic rhinitis and allergic asthma compared with patients with allergic rhinitis only
There were no differences of Total nasal symptom score (TNSS), Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) and Pittsburgh Sleep Quality Index (PSQI) scores between patients with allergic rhinitis and allergic asthma and patients with allergic rhinitis only (Table 1)
Summary
Persistent allergic airway diseases cause a great burden worldwide. The aim of this study was to investigate IL-22 level in patients with persistent allergic airway diseases caused by house dust mite (HDM) in comparison with healthy individuals and to evaluate its relationship with IL-13 and IL-10 level, symptoms score and quality of life. For better management of allergic airway diseases, it is important to determine its phenotype and endotype. This can ensure personalized approach, treatment options and prognosis for current patient especially when common medications are not effective enough. That is why scientists are still investigating immunologic mechanisms that can be important in the development of allergic rhinitis and allergic asthma
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
