Abstract
Oral Lichen Planus (OLP) is a chronic inflammatory disease with a cell-mediated immunopathologic response. Although OLP has been studied extensively for decades, its exactaetiologyremains unclear. Autoimmunity, viruses like Hepatitis C Virus (HCV), Human Papillomavirus (HPV), and stress have all beenhypothesized in recent articles. HPVs are epitheliotropic viruses with an affinity for keratinocytes and are principally found in the anogenital tract, urethra, skin, larynx, tracheobronchial and oral mucosa. This article aimed to review the frequency of HPV prevalence in OLP. A computer database search was performed through the use of PubMed from 1987 to 2021. The summary showed that the association of HPV and OLP varied significantly by geographic population. The correlation of HPV and erosive-atrophic oral lichen planus was comparable and well above that of HPV and non-EA-OLP. Among HPV genotypes, HPV 16 showed an extremely strong association with OLP, and HPV 18 showed a relatively strong one.
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