Abstract
Introduction. Coronary heart disease is closely associated with modifiable risk factors such as hypertension, smoking, obesity, dyslipidaemia, and diabetes. At the same time, the role of family history of cardiovascular diseases (CVD) as an independent and significant risk factor for CHD is still unclear. Or may a family history of cardiovascular diseases be largely explained by a combination of traditional risk factors? Materials and methods of the study. By means of the information retrieval system of the Dimol complex, reliable group of male siblings (86 patients) with a horizontal hereditary burden of CHD (through male siblings) was formed. The study was conducted basing on the analysis of risk factors for CHD in studied patients. The obtained results were compared with published statistical data on the prevalence of risk factors for coronary heart disease among men in the Russian Federation. Results. According to our study, the prevalence of smoking habit among male siblings was 55.8%, arterial hypertension – 74.4%, abdominal obesity – 40.7%, diabetes – 20.9%, hypercholesterolemia – 58.1%. The predicted incidence of CHD according to the CAD Consortium scale was 51% (41–64). At the same time, according to the CAG and CA-MSCT findings, stenosis lesions of coronary arteries were found in 74 (86%) male siblings. Conclusions. According to our analysis, the prevalence of CHD risk factors in male siblings with exertional angina is higher than the average in the male population of the Russian Federation. Horizontal hereditary CVD burden is an independent and significant risk factor for CHD in the group of male siblings. Keywords: CHD risk factors, siblings, hereditary burden
Published Version
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