Role of Gamma-Aminobutyric Acid in the Antiepileptic Activity of Garcinia Mangostana Standardized Extract

Abstract

Epilepsy is a neurodegenerative disorder characterized by recurrent seizure activity, accompanied by convulsions and loss of consciousness. The aim of the present study was to investigate the antiepileptic activity of GML in mice using MES- and INH-induced models. Estimation of brain GABA levels and in vitro antioxidant potential was also evaluated. Treatment of mice with GML significantly reversed the MES-induced convulsions, which was reflected by the decrease in the duration (in seconds) of all the phases, with an increment in the GABA levels. In the INH model, animals treated with test drug exhibited a significant delay in the onset (in minutes) of clonic convulsions, and a decrease in the duration (in minutes) of clonic convulsions. GML had a dose dependent positive effect on GABAergic neurotransmission that was evident by a significant increase in the brain GABA levels. GML also exhibited significant free radical scavenging (DPPH•), reducing power, and hydroxyl radical scavenging activity. Put together, the data from the current study suggests that GML has significant antiepileptic potential, modulated through positive GABAergic neurotransmission and antioxidant properties.