Role of free radicals and antioxidants in cervical cancer in southern part of Rajasthan

Abstract

Introduction: Present study is conducted to measure the role of free radicals malondialdehyde and vitamin-C and vitamin-E in cervical cancer women in southern part of Rajasthan. Materials and Methods: Total 80 cases and controls were taken and level of MDA were determined by the Thiobarbituric acid (TBA) test which is the colorimetric reaction of MDA and TBA in acid solution. Vitamin C was determined by the method of Natelson, (1971). Vitamin E was determined by Baker and Frank method. Results: The serum level of malondialdehyde, vitamin-C and vitamin-E level in cervix cancer patients and controls using paired t-test for independent means and found that a statistically significant difference exist between case and controls. Conclusion: Present study concluded that serum levels of vitamin C and vitamin E decreases and level of MDA increases in cervix cancer patients. So the serum levels of these micronutrients as a marker in early diagnosis of cervix cancer as adjuvant to other methods as well as by providing supplementation of these micronutrients. Keywords: Cervix carcinoma, Malondialdehyde, Oxidative stress, Polyunsaturated fatty acid, Thiobarbituric acid reactive substances, Antioxidant vitamins.