Abstract
Background and Aims: Engulfment of oxidized low-density lipoprotein (ox-LDL) by macrophages to form foam cells is a key hallmark of the atherosclerotic cardiovascular disease, a leading cause of death in patients with diabetes. Recent application of single cell RNA sequencing (scRNA-seq) of CD45+ cells identified 13 immune cell types with three distinct macrophage populations including Trem2hi foamy macrophages in western diet fed Apoe-/-. Although it is evident that cellular phenotypes are altered by the diabetic environment, the molecular mechanisms underlying diabetes-induced foam cell formation are not known.
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