Role of follicular dendritic cells in the regulation of B cell proliferation.

Abstract

Within secondary lymphoid organs, B and T lymphocytes are not randomly distributed but they specifically inhabit highly organized regions that contain areas where B and T cells are largely segregated and other areas where different populations of cells can interact and differentiate (Thorbecke et al. 1962). Specifically, in lymph nodes and tonsils, the majority of B cells localize to follicles, whereas most T cells are found in the paracortex (Nieuwenhuis and Ford 1976). Following initial entrance into the interfollicular areas of secondary lymphoid tissues, it is not known what drives B cells to localize to follicles; however, the formation of follicles is an antigen (Ag)-driven process that requires the presence and participation of T lymphocytes.KeywordsHairy Cell LeukemiaFollicular Dendritic CellInterfollicular AreaStimulate Tyrosine PhosphorylationStaphylococcus Aureus CowanThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.