Abstract
Canonical estrogen receptors (ER α/β) have a genomic mechanism of action, functioning as nuclear transcription factors for estrogen-dependent genes. Estrogen receptors are well established within the male reproductive tract with estrogen playing an essential role for male fertility. The recent characterization of novel G-protein coupled estrogen receptor GPR30 (alternatively known as GPER1), depending on non-genomic intracellular signaling pathways to transduce estrogenic signals, requires a re-examination of the roles of estrogen receptors in male reproduction. Further, the affinity of environmental estrogens (xenoestrogens) for estrogen receptor subtypes may provide additional understanding of the reproductive effects of these chemicals on male fertility. Here we review the structure and functions of each estrogen receptor within the context of male reproduction, with special consideration of the reproductive implications of xenoestrogen exposure.
Highlights
La caractérisation récente du nouveau récepteur œstrogénique couplé à une pro- téine G GPR30, reposant sur la capacité des voies de signalisation intracellulaires non génomiques de transduire des signaux œstrogéniques, nécessite un réexamen du rôle des récepteurs des œstrogènes au niveau de la reproduction masculine
Estrogen receptors are known as liganddependent transcription factors which have been found to be located within the confines of the cell’s membrane and bind the steroidal hormone estrogen (Hess et al, 1997). These conventional nuclear steroidal receptors have been identified as ERα and Estrogen Receptor-β (ERβ), where ERβ was discovered less than 20 years ago in 1996
ERα is vation response can occur via initiation of a mitogen activated protein kinases (MAPK) pathway through the means the major species expressed in the uterus, liver, adipose of a known cell surface estrogen receptor
Summary
La caractérisation récente du nouveau récepteur œstrogénique couplé à une pro- téine G GPR30 (également connue sous GPER1), reposant sur la capacité des voies de signalisation intracellulaires non génomiques de transduire des signaux œstrogéniques, nécessite un réexamen du rôle des récepteurs des œstrogènes au niveau de la reproduction masculine. ERα is vation response (as a result of S118 phosphorylation) can occur via initiation of a MAPK pathway through the means the major species expressed in the uterus, liver, adipose of a known cell surface estrogen receptor.
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