Abstract
CONCLUSION: •Patients with prostate cancer with overexpression of either or both EGFR and HER2 on IHC have an increased risk of biochemical relapse after radical radiotherapy. Alternative strategies of either surgery or utilization of EGFR and HER2 inhibition combined with radiotherapy need to be considered for such patients. :EGFR and HER2 expression was evaluated by immunohistochemistry (IHC) in 84 patients treated with radical radiotherapy in the Northern Centre for Cancer Treatment, in Newcastle in the UK between 1996 and 2000.
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